KMID : 0191120120270050572
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Journal of Korean Medical Science 2012 Volume.27 No. 5 p.572 ~ p.575
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Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim Seok-Jai
Jeong Cheol-Won Bae Hong-Beom Kwak Sang-Hyun Son Jong-Keun Seo Chang-Seob Lee Hyun-Jung Lee Jong-Un Yoo Kyung-Yeon
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Abstract
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Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of the left anterior descending coronary artery, followed by 2 hr reperfusion. Sauchinone (10 mg/kg) was administered intraperitoneally 30 min before the onset of ischemia. The infarct size was measured 2 hr after resuming the perfusion. The expression of cell death kinases (p38 and JNK) and reperfusion injury salvage kinases (phosphatidylinositol-3-OH kinases-Akt, extra-cellular signal-regulated kinases [ERK1/2])/glycogen synthase kinase (GSK)-3¥â was determined 5 min after resuming the perfusion. Sauchinone significantly reduced the infarct size (29.0% ¡¾ 5.3% in the sauchinone group vs 44.4% ¡¾ 6.1% in the control, P < 0.05). Accordingly, the phosphorylation of JNK and p38 was significantly attenuated, while that of ERK1/2, Akt and GSK-3¥â was not affected. It is suggested that sauchinone protects against regional myocardial I/R injury through inhibition of phosphorylation of p38 and JNK death signaling pathways.
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KEYWORD
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Sauchinone, Cardioprotection, Ischemia/reperfusion Injury, Cell Death Signaling Pathway, Reperfusion Injury Salvage Kinase Pathway
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